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Much like sublingual and buccal routes, rectally administered drugs go through passive diffusion and partially bypass the main-go metabolism. Only about 50 % from the drug absorbed while in the rectum straight goes to your liver.[two] The 3rd phase of pharmacokinetics that involves the breakdown of a drug to make sure that it could be excreted by
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the place H equals HETP, A will be the term for eddy diffusion, B is the term for longitudinal diffusion, C is the coefficient for mass-transfer between the stationary and cell phases, and u will be the linear velocity. The equation for HETP is often made use of to explain the effectiveness on the column.b) Gradient separation: Listed below are two